BINC shared the results of Biostime's innovative mother and infant research, appeared at the 2021 Congress of Chinese Pediatric Society
Wuhan, China13932021/10/26 Favorite

The theme of this conference is to promote the prosperity and development of China's pediatric medicine discipline, continuously promote the progress and innovation of pediatric medicine, and protect children's health and life safety. A number of well-known pediatric experts at home and abroad were invited to the conference site to give special reports and in-depth discussions on the latest research hotspots and cutting-edge issues in the field of pediatrics. At the same time, various forms of exchanges such as booths, poster exchanges, and medical records discussions were set up, with experts and scholars in the maternal and infant field enjoying this academic and industrial feast.

The Congressof Chinese Pediatric Society is an annual event in the field of childhealth in China, attracting many experts and scholars from all walks of life,as well as maternal and child health companies. Since Biostime Institute of Nutrition and Care (BINC) established, it has continued to deepen thescientific research on breast milk components, actively cooperates with scientific research institutions, experts and scholars. BINC has invested more than 10million in support of public welfare maternal and child health research projectsat home and abroad. The research results are applied to the research anddevelopment of infant formula milk powder, in an effort to provide precise and personalized solutions to maternal and infant health problems. In order toshare academic achievements, BINC participated in the conference with Biostime's innovative maternal and child research results, and set up boothsand academic posters to communicate and discuss maternal and child healthissues with authoritative experts in the field. The sharing content alsoreceived extensive attention from participating experts.

Wang Tianyou (second from the right), chairmanof the science branch of the Chinese Medical Association and President of the conference,visited binc booth with the leaders of the society.

BINC booth attracted the attention of manyparticipating experts.

Osteopontin (OPN) contributes to the immunehealth of infants and young children

Osteopontin is one of the rich proteins inbreast milk and has been the focus of research in the field of maternal andinfant health in recent years. Studies have found that the content of OPN inChinese mothers’ breast milk can be as high as 266 mg/L. Biostime took the leadin completing the world's first OPN clinical study for Chinese babies. Theresults showed that compared with ordinary formula powder, the infants fed bythe OPN formula group had significantly less fever and were closer to breastfedinfants, and OPN helped to support the development of the immune system earlyin life.

OPN can inhibit inflammatory cytokines andaffect immune function.


HMOs affect the structure and growth of infantintestinal flora

Human milk oligosaccharides (HMOs) are thethird most abundant solid component in breast milk, and play a key role inregulating the intestinal flora and intestinal barrier function of infants. Inorder to explore the composition of breast milk oligosaccharides secreted byindividual mothers of different regions or different genotypes, and theirimpact on infant health, Biostime Innovation Research Center conducted a cohortstudy in conjunction with several authoritative scientific researchinstitutions.

Studies have shown that in the first three months of postpartum, the diversity of the intestinal flora of breast milk and infants gradually increases with the extension of the feeding time. The structure and growth of the intestinal flora in early infants are closely related to sialylated HMOs and Bifidobacteria in breast milk. This research provides atheoretical basis for future research on the mechanism of HMOs affecting infanthealth and personalized nutrition intervention for infants and young children.

Diagram of relative abundance of microflora inbreast milk and infant intestines.

(A-breast milk; B-baby gastrointestinal tract)

The core fucosylation of breast milk proteinregulates the intestinal flora and immune response of offspring

High fucosylation is a general feature of humanmilk. In order to explore the influence of the core fucosylation of milkprotein on the growth and development of offspring, BINC and Professor Li Ming,School of Basic Medicine, Dalian Medical University, launched a BINC fundinnovative research project. This project explored the effects of milk proteincore-fucosylation on gut microbiota and B cell development of neonates fedmaternal mice. The study showed that the core fucosylation of breast milkprotein has an impact on the structure of the offspring's intestinal flora, and that changes in the structure of the intestinal flora can affect the development of B lymphocytes.

Maternal mice-fed neonates showed lowerproportion of splenic CD19+CD69+ B lymphocytes.

SN-2 palmitate helps promote fatty acid andcalcium absorption

For babies, milk fat is an important source offat. Biostime completed the first clinical study of milk fat for Chinese babies, and examined the tolerance and efficacy of formula powder rich in SN-2palmitate for infants and young children. The results showed that SN2-palmitateinfant formula milk powder can reduce the excretion of calcium saponified fat,thereby promoting the absorption of fatty acids and calcium by infants andyoung children.

Infants in the SN-2 palmitate group had lowerfecal dry weight and lower total fatty acid excretion.

The successful holding of this conferenceprovides BINC with a valuable academic exchange platform, enabling Biostime'sinnovative research results to gain the attention and recognition ofauthoritative experts and scholars. At the same time, it provide new vision anddirection for Biostime maternal and child health research in the future, to promotethe development of scientific research in the field of maternal and childhealth.

 "Dedicate to science, care mother and children"is the mission that BINC has always insisted on. In the future, BINC willcontinue to work with domestic and foreign authoritative institutions, expertsand scholars to deepen the innovation of active ingredients in breast milk,adhere to the organic combination of scientific research and industrializationof results, and jointly weave a guardian network for maternal and infanthealth, and continue to promote the vigorous development of maternal and infantbusiness.

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